Cape Girardeau, MO 63701
Find a cozy hotel in historic Missouri at Hampton Inn Cape Girardeau. Just off the I-55, you’ll find the Hampton Inn Cape Girardeau hotel at the heart of this charming city. With 39 historic sites on the National Register, Cape Girardeau was once the busiest steamboat port on the Mississippi River. These days, you can watch riverboats dock from Riverfront Park, visit the Fort D historic site and enjoy browsing the many antique stores of well-preserved downtown Cape Girardeau, MO.